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To examine whether transgene-mediated overexpression of serpina3n produced superior inhibition of endogenous serine protease activity in vivo , we performed acute injury with ctx injection into the ta muscle and then assessed protease activity over 6 days fig.
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The mutations that are found in the serpina gene lead to what is now known as alpha 1 antitrypsin deficiency, especially if there is an error in the mentioned gene.
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